**Figure 1.** **The lifespan of Dom, Sub and BS mice.** The Kaplan-Meier survival curves of Dom, Sub and BS mice in (**A**) males (log-rank test, *p*<0.001;n=30 for Dom and n=34 for Sub, and n=10 for BS), and (**B**) females (log-rank test, *p*<0.05; n=13 for Dom and n=23 for Sub, and n=10 for BS), (**C**) Sub naïve (n=20) and exposed to CMS (n=20) males. * - *p*<0.05, *** - *p*<0.001.