Figure 1. CCL21 and prognosis in acute coronary syndromes. (A) (1) CCL21 may contribute to atherogenesis by different mechanisms including recruitment of T cells and macrophages to atherosclerotic lesions and induction of a matrix degrading, pro-thrombotic and inflammatory phenotype in these and other vascular cells leading to atheroma formation (2) and potentially thrombosis and myocardial infarction (3). CCL21/CCr7 interactions are also involved in adverse cardia remodeling and high circulating levels (4) are associated with poor outcome in patients with cardiac dysfunction. (B) We recently reported that CCL21 was associated with MACE following ACS and further analysis shows that this association is most prominent in NSTEMI.