Research Paper Volume 11, Issue 24 pp 11814—11828

Circadian clock associates with tumor microenvironment in thoracic cancers

Figure 1. Core circadian clock genes are altered in thoracic cancers. (A) The circadian rhythm of core circadian genes, including CRY2, PER1, RORA, NR1D1, CLOCK, CRY1, PER3, PER2, and ARNTL. (B) The methylation difference between tumors and normal tissues. (C) The methylation level affects the core circadian gene expressions. Abbreviations: LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; ESCA, esophageal carcinoma.