Research Paper Volume 11, Issue 24 pp 11829—11843

Suppression of FADS1 induces ROS generation, cell cycle arrest, and apoptosis in melanocytes: implications for vitiligo

Figure 8. Downregulation of FADS1 inhibited melanogenesis by inhibiting the MAPK signaling pathway. PIG1 cells were transfected with NC-siRNA or FADS1-siRNA2 for 72 h. (A) Western blot detection of p-p38 and p-JNK expression. β-actin was used as internal control. (B, C) Relative expression of p-p38 and p-JNK after normalization to p38 and JNK. **P < 0.01, compared with the NC group.