Research Paper Volume 11, Issue 24 pp 11988—12001

CircRNA AFF4 promotes osteoblast cells proliferation and inhibits apoptosis via the Mir-7223-5p/PIK3R1 axis

Figure 7. Mechanisms of circRNA AFF4 mediated fracture healing. CircRNA AFF4 acts as sponge of miR-7223-5p, leading to PI3K-AKT activation, which accelerates fracture healing via promoting cell proliferation and inhibiting apoptosis.