Research Paper Volume 11, Issue 24 pp 12002—12031

Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice

Figure 4. CircNF1-419 participates in the regulation of autophagy in astrocyte. The expression of PI3Kp85, PI3Kp100, AMPK, Atg13, ULK1, Beclin-1, Atg14, Atg5, Atg12, LC3A, LC3B I and LC3B II proteins in the over-expressing circNF1-419-transfected rat astrocyte were measured by using western blotting. Data are presented as the means±SD of 3 independent experiments. *p <0.05 and **p <0.01 vs. the WT by one-way ANOVA, followed by the Holm-Sidak test.