Figure 5. Autophagy level in the age-related disease model animals. The expression of Atg12 (A, B), LC3A (A, C), LC3B I (A, D) and LC3B II (A, E) protein in the 8 months old APP/PS1 and SAMP8 mice were measured using western blot (A–E). Data are presented as the means ± SD of 3 independent experiments. #p <0.05 vs. the control group, *p <0.05 and **p <0.01 vs. the model group by one-way ANOVA, followed by the Holm-Sidak test.