Figure 9. Significant related genes and hallmarks pathways in ccRCC obtained by GSEA. A total of 100 significant genes were obtained by GSEA with positive and negative correlation. (A–E) The most involved significant pathways included angiogenesis, apical junction, hedgehog signaling, TGF-beta signaling, and WNT/β/CATEMIN signaling. (F) Transcriptional expression profiles of the 100 significant genes were performed in a heat map.