Research Paper Volume 11, Issue 24 pp 12147—12164

Hematoma-derived exosomes of chronic subdural hematoma promote abnormal angiogenesis and inhibit hematoma absorption through miR-144-5p

Figure 7. Over-expression of miR-144-5p promoted tube formation, increased cell permeability, increased ANG-2 expression, and decreased ANG-1 expression in HUVECs. (A) Representative images of tube formation. (BD) Quantification of branches, tubes, and tube length. (E) Effects of miR-144-5p over-expression on the permeability of HUVEC monolayers to FITC-Dextran. (F) Representative images of western blots showing ANG-1 and ANG-2 expression. (GH) Quantification of ANG-1 and ANG-2 expression.* p < 0.05, ** p < 0.01, # p < 0.05.