Research Paper Volume 11, Issue 24 pp 12147—12164

Hematoma-derived exosomes of chronic subdural hematoma promote abnormal angiogenesis and inhibit hematoma absorption through miR-144-5p

Figure 8. Over-expression of miR-144-5p results in decreased hematoma absorption, increased ANG-2 expression, and decreased ANG-1 expression in SDH rats. (A) Representative MR images of SDH rats at baseline and day 7. (B) Quantification of the percentage of hematoma absorption at baseline compared to day 7. Decreased hematoma absorption on day 7 was observed in the SDH + miRNA mimic group compared to the saline and negative control (NC) groups. (C) Representative images of western blots demonstrating differences in ANG-1 and ANG-2 expression. (D,E) Quantification of ANG-1 and ANG-2 expression. ** p < 0.01, ***p < 0.001, ## p < 0.01, ### p < 0.001.