Research Paper Volume 11, Issue 24 pp 12236—12245

Improved therapeutic effects on diabetic foot by human mesenchymal stem cells expressing MALAT1 as a sponge for microRNA-205-5p

Figure 3. Ectopic expression of MALAT1 improves endothelial cell tube formation in vitro. (A) Schematic of a transwell co-culture system, in which HUVECs in the lower chamber were co-cultured with different MSCs (null-MSCs, as-miR-205-5p-MSCs, MALAT1-MSCs) seeded in the upper chamber. Analysis on the tube formation by HUVECs was done 3 days after co-culture. (B, C) Tube formation was assessed, shown by representative images (B), and by quantification (C). *p<0.05. N=5. Scale bars are 50μm.