Research Paper Volume 11, Issue 24 pp 12236—12245

Improved therapeutic effects on diabetic foot by human mesenchymal stem cells expressing MALAT1 as a sponge for microRNA-205-5p

Figure 5. Overexpression of MALAT1 in grafted MSCs exhibits better therapeutic potential on DF than depletion of miR-205-5p in grafted MSCs. (A) Quantification of ulcer area 4 weeks after MSC transplantation. (B) ELISA for VEGF fold change in ulcer tissue. (C, D) Quantification of vessel density 4 weeks after MSC transplantation, shown by quantification of fold change (C), and by representative images (D). *p<0.05. N=10. Scale bars are 150 μm.