Research Paper Volume 11, Issue 24 pp 12270—12277

Relationship between PD-L1 expression and 18F-FDG uptake in gastric cancer

Figure 1. The association between 18F-FDG accumulation and PD-L1/PD-L1-TILs status in gastric cancer (n=64). (A) The association between 18F-FDG accumulation and PD-L1 status. Gastric cancers with positive PD-L1 had higher SUVmax compared with those lacking PD-L1 (15.0 ± 8.0 vs. 7.2 ± 4.2, respectively; P = 0.004). (B) The association between 18F-FDG accumulation and PD-L1-TILs status. Gastric cancers with positive PD-L1-TILs had higher SUVmax compared with those lacking PD-L1-TILs (10.3 ± 6.5 vs. 6.6 ± 3.7, respectively; P = 0.034). (C) ROC analysis of SUVmax for predicting PD-L1 status. When the cutoff threshold of SUVmax was 8.55, the sensitivity and specificity to predict PD-L1 status was 85.7% and 64.9%, respectively. The area under curve was 0.822 (95% CI: 0.674-0.97; P = 0.006). (D) ROC analysis of SUVmax for predicting PD-L1-TILs status. When the cutoff threshold of SUVmax was 7.9, the sensitivity and specificity to predict PD-L1-TILs was 60.0% and 66.7%, respectively. The area under curve was 0.658 (95% CI: 0.52-0.796; P = 0.034).