Research Paper Volume 11, Issue 24 pp 12295—12314

ERK1 indicates good prognosis and inhibits breast cancer progression by suppressing YAP1 signaling

Figure 3. ERK1 was negatively associated with YAP1 signaling genes in breast cancer cells. (A) GSEA of expression data from breast cancer cell lines revealed enrichment of conserved YAP1 target genes in ERK1 low expression cell lines compared with those with high ERK1 expression. NES, normalized enrichment score. (B) Pearson correlation analysis showed that ERK1 expression levels were negatively correlated with YAP1 and its target gene expression (GLS, ASAP1, MARCKS) in 50 breast cancer cell lines analyzed. (C) List of the Pearson analysis of correlation between several YAP1 target genes and ERK1 in 50 breast cancer cell lines. (D) Heat map showing low expression levels of ERK1 enriched high expression of YAP1 signaling-related genes in breast cancer cell lines.