Research Paper Volume 11, Issue 24 pp 12315—12327

β-arrestin2 alleviates L-dopa–induced dyskinesia via lower D1R activity in Parkinson’s rats

Figure 2. AAV-Mediated β-arrestin2 overexpression reduces AIMs induced by L-dopa in 6-OHDA-lesioned rats. Rats were rated for AIMs on days 1, 3, 5, 7, 11, 13, 15, 17, 19 and 21 and carried on testing on days 2, 4, 6 and 8 after the striatum-targeted injection of β-arrestin2+/+ (n=8 for each group, total n=40 rats). (A) Total AIM scores measured after L-dopa or saline injection in all groups; (B) axial AIM score; (C) limb AIM score; (D) orolingual AIM score; (E) Forelimb functional test. Data are displayed as average ± standard error; @ P<0.0001 vs LID, ## P > 0.05 (n = 8 for each group, Kruskal Wallis followed by Dunn’s test for multiple comparisons or two-tailed unpaired t test).