Research Paper Volume 11, Issue 24 pp 12345—12360

Circular RNA SMO sponges miR-338-3p to promote the growth of glioma by enhancing the expression of SMO

Figure 3. CircSMO742 and SMO were simultaneously targeted by miR-338-3p. (AD) Expression level of circSMO742, miR-338-3p, SMO mRNA and protein in different groups, NC, circSMO742 over-expressed, circSMO742 knockdown, measured with qRT-PCR and western blot assay. The level of circSMO742 (E) and SMO (G) in U-87 MG cells captured with miR-338-3p-biotin probes were higher compared with NC-probe, respectively. The direct interaction between circSMO742 and miR-338-3p (F) or SMO and miR-338-3p (H) was detected by dual luciferase reporter assays. *P<0.05, v.s. NC group.