Research Paper Volume 11, Issue 24 pp 12345—12360

Circular RNA SMO sponges miR-338-3p to promote the growth of glioma by enhancing the expression of SMO

Figure 8. Schematic diagram of endogenous competition mechanism. CircSMO742 and SMO mRNA derived from a parent gene of SMO and circSMO742 circled from 4 exons. In glioma, circSMO742 was up-regulation could sponge miR-338-3p a lot to let parent gene largely coding SMO mRNA, encoding SMO protein to promote cell proliferation, migration and invasion.