A phenolic amide (LyA) isolated from the fruits of <i>Lycium barbarum</i> protects against cerebral ischemia–reperfusion injury via PKCε/Nrf2/HO-1 pathway

Kai Gao; Meiyou Liu; Yi Ding; Minna Yao; Yanrong Zhu; Jinyi Zhao; Lianghua Cheng; Juan Bai; Fan Wang; Jinyi Cao; Jiankang Li; Haifeng Tang; Yanyan Jia; Aidong Wen

doi:doi:10.18632/aging.102578

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Research Paper Volume 11, Issue 24 pp 12361—12374

A phenolic amide (LyA) isolated from the fruits of Lycium barbarum protects against cerebral ischemia–reperfusion injury via PKCε/Nrf2/HO-1 pathway

Figure 1. Effects of phenolic amides and OGD on cell viability. (A) Chemical structure of phenolic amides (1-5). Thereinto, the compound 3 is Lyciumamide A (LyA). (B) MTT assay was employed to investigate the protective effects of phenolic amides against OGD-induced cytotoxicity. The concentrations of these compounds is 40 μM. Data were represented as means ± SD (n=6). ^* p < 0.05 compared with control group; ^# p < 0.05 compared with OGD group.