Research Paper Volume 11, Issue 24 pp 12361—12374

A phenolic amide (LyA) isolated from the fruits of Lycium barbarum protects against cerebral ischemia–reperfusion injury via PKCε/Nrf2/HO-1 pathway


Figure 2. LyA protects against cerebral ischemic-reperfusion injury. (A) TTC staining of the cerebral infarct in the sham, control and treatment with LyA groups. (B) The columnar diagram for the infarct volume of brains in each group (n=6). (C) Neurological scores of rats at 48 h after cerebral I/R for each group (n=8). (D) H-E stains of coronal sections from the ischemic cerebral cortex (scale bar 100 μm). (E) Necrotic neurons were counted and analyzed in each group (n=6). All data, except for neurological scores, were expressed as mean ± SD. * p < 0.05 compared with sham group; # p < 0.05 compared with I/R group.