Research Paper Volume 11, Issue 24 pp 12497—12531

Age-related changes in eye lens biomechanics, morphology, refractive index and transparency

Figure 13. Average GRIN profiles along the visual axis and maximum refractive index in lenses from mice between 2 weeks to 24 months of age. Lines on the plots reflect mean ± SD of n = at least 3 lenses from different mice per age. The graph next to the data plots shows the 95% confidence interval. Any comparisons not crossing the dotted line are statistically significant (p < 0.05). (A) Average GRIN profiles increased in magnitude until about 6 months of age and then remained relatively unchanged with age. There is a statistically significant difference between profiles of different ages, except between the 12 months and 24 months profiles. (B) Max refractive index is ~1.55 in mouse lenses. Maximum refractive index rapidly increases until 6 months of age and then remains steady after 6 months of age.