Research Paper Volume 11, Issue 24 pp 12497—12531

Age-related changes in eye lens biomechanics, morphology, refractive index and transparency

Figure 6. Lens images (top down view) from mice between 2-30 months of age in various B6 wild-type backgrounds. (A) B6-albino wild-type mice have clear lenses up to 8 months of age and develop small anterior opacities (arrowheads) by 12 months of age. Lenses from mice between 12-18 months develop cortical haziness (asterisks). Old lenses from mice between 24-30 months display ring cataracts (arrows) with a clear periphery and translucent, but not transparent, central regions. (B, C) Similar to B6-albino wild-type lenses, C57BL6 and B6SJL wild-type lenses also develop anterior opacities (arrowheads), cortical haziness (asterisks) and ring cataracts (arrows) at the same age as B6-albino wild-type mice. These images reveal that aged mouse lenses in the B6 genetic background develop cataracts around 12 months of age at the anterior pole and the lens cortex (haziness and ring opacity). Scale bars, 1mm.