Research Paper Volume 11, Issue 24 pp 12600—12623

Genome-wide global identification of NRF2 binding sites in A549 non-small cell lung cancer cells by ChIP-Seq reveals NRF2 regulation of genes involved in focal adhesion pathways

Figure 1. Genome-wide annotation of NRF2-binding sites and response elements in A549 NSCLC cells. (A) Distribution of NRF2 transcription factor binding sites relative to the nearest TSS across the human genome (x-axis, number of peaks in the genome; y-axis, distance relative to the TSS from –10 KB to +10 KB). (B) Pie chart of the percentages of NRF2-binding sites according to peak location across different genomic regions of the human genome. (C) Bar chart of the numbers of NRF2-binding sites categorized according to peak location across the human genome.