Research Paper Volume 11, Issue 24 pp 12600—12623

Genome-wide global identification of NRF2 binding sites in A549 non-small cell lung cancer cells by ChIP-Seq reveals NRF2 regulation of genes involved in focal adhesion pathways

Figure 3. Visualization of NRF2 binding sites obtained from the UCSC genome browser (version hg19). (AC) Locations of AREs in the promoter regions of the known NRF2 target genes NQO1 (A), PRDX1 (B), and TXN (C). The peaks represent the 150-bp binding regions identified from our ChIP-Seq results (boxes ARE sequences; ticks, ARE positions; blocks, coding exons; horizontal lines with arrows connecting exons represent introns).