Research Paper Volume 11, Issue 24 pp 12641—12660

Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair

Figure 4. Transplantation of MIF-aged MSCs improved cardiac function in a rat model of MI. (A) Representative images of M-mode echocardiography captured 28 days after MI in rats from the different groups. (B) Heart function, including the LVEF and LVFS, was evaluated at 0, 7 and 28 days in control mice and MI mice with or without MSC transplantation. (C) Representative images of Masson's Trichrome staining and quantitative analysis of heart fibrosis in the different experimental groups. Scale bar=2 mm. Data are expressed as the mean±SEM. n=6-7. **p<0.01; ***p<0.001.