Research Paper Volume 11, Issue 24 pp 12754—12772

Expression profile-based screening for critical genes reveals S100A4, ACKR3 and CDH1 in docetaxel-resistant prostate cancer cells

Figure 3. PPI networks constructed using the DEGs from microarray data. (A) Network of significant proteins from DU145R cells. (B) Network of significant proteins from PC3R cells. (C) Network derived from panel A with first-stage nodes associated with the core proteins S100A4, ACKR3 and CDH1. (D) Network derived from panel B with first neighbors associated with the core proteins S100A4, ACKR3 and CDH1. (E) Significant hub proteins extracted from network C. (F) Significant hub proteins extracted from network D. Red and green intensities indicate the degree of upregulation and downregulation, respectively.