Research Paper Volume 12, Issue 2 pp 1186—1200

Fibroblast growth factor 10 alleviates particulate matter-induced lung injury by inhibiting the HMGB1-TLR4 pathway

Figure 1. Pretreatment with FGF10 reduced the inflammation in response to PM exposure in vivo. Mice were intratracheally treated with 5 mg/kg of FGF10 solution at one hour in advance, after which these were intratracheally instilled with 100 μg of PM/day/mouse over two consecutive days. (A) The representative H&E stained lung sections. (B) The inflammatory scores for the H&E stained lung sections (n=3/group). (C) The total BALF protein as measured via the BCA assay. (D and E) The BALF HMGB1, IL-6, IL-8 and TNF-α protein levels as quantified by ELISA. Data were presented as mean ± standard error of the mean (SEM, n=3); *P<0.05, **P<0.01 vs. control. #P<0.05, ##P<0.01 vs. PM.