Research Paper Volume 12, Issue 2 pp 1304—1321

AURKB promotes gastric cancer progression via activation of CCND1 expression

Figure 6. Inhibition of AURKB kinase activity represses the expression of CCND1 and decreases gastric cancer growth in vivo. (A) Photograph of xenograft tumors excised from mice treated with AZD1152 (25 mg/kg). (B) Tumor volumes were examined on the indicated days. Data are presented as the means ± SDs; **, P < 0.01. (C) Tumor mass of xenograft tumors excised from mice treated with AZD1152 (25 mg/kg). (D) Western blot analysis of AURKB, CCND1 and H3S10ph expression in xenograft tumors treated with AZD1152 (25 mg/kg). HSP70 and histone H3 were used as the endogenous controls. (E) Hematoxylin and eosin (H&E) staining and IHC staining of AURKB, CCND1, H3S10ph and Ki-67 in xenograft tumors excised from mice treated with AZD1152 (25 mg/kg) and control.