Research Paper Volume 12, Issue 2 pp 1332—1365

Identification of key genes by integrating DNA methylation and next-generation transcriptome sequencing for esophageal squamous cell carcinoma

Figure 6. Inverse trend between DNA methylation and histone modification of SIX4 in ESCC. Blue tracks represent the histone modifications of SIX4 in five ESCC cell lines, and yellow tracks represent its methylation level, as measured by the WGBS assay, all the tracks are on the same scale (0-1). Scatter diagrams show the Δβ of SIX4 in ESCC samples compared with normal samples. Histograms show the correlation between DNA methylation and gene expression of SIX4.