Research Paper Volume 12, Issue 2 pp 1417—1432

SRV2 promotes mitochondrial fission and Mst1-Drp1 signaling in LPS-induced septic cardiomyopathy

Figure 8. A summary diagram of our results. SRV2 is upregulated in response to LPS-induced septic cardiomyopathy. Excessive SRV2 upregulates Mst1 and Drp1, which in turn activate mitochondrial fission. Excessive fission induces cardiomyocyte death by promoting mitochondrial oxidative stress and inflammatory response and disrupting energy metabolism.