Research Paper Volume 12, Issue 2 pp 1446—1464

Immunological analyses reveal an immune subtype of uveal melanoma with a poor prognosis

Figure 6. The prognostic value of individual immune genes in UM. (A) Kaplan-Meier survival curves demonstrate that elevated levels of CD8A (P<0.0001), HLA-A (P<0.0001), HLA-B (P=0.0001), HLA-C (P=0.0003) and HLA-DRA (P=0.0001) were consistently associated with worse OS in the UM dataset of TCGA. (B) Kaplan-Meier survival curves demonstrate that elevated levels of CD8A, HLA-A, HLA-B, HLA-C and HLA-DRA were consistently associated with a worse PFI in the UM dataset of TCGA (log-rank test, P<0.05). (C) Kaplan-Meier survival curves demonstrate that elevated levels of CD8A (P=0.06), HLA-A (P=0.02), HLA-B (P=0.002), HLA-C (P=0.007) and HLA-DRA (P=0.03) were consistently associated with worse metastasis-free survival in the Laurent UM dataset (n=63; log-rank test, P<0.05).