Research Paper Volume 12, Issue 2 pp 1465—1487

MTDH promotes metastasis of clear cell renal cell carcinoma by activating SND1-mediated ERK signaling and epithelial-mesenchymal transition

Figure 1. The relative mRNA expression levels of MTDH in ccRCC patients. (A) Based on GEO datasets, the mRNA expression of MTDH was significantly up-regulated in ccRCC tissues compared with normal kidney tissue in all 10 ccRCC GEO datasets. (B) The result of meta-analysis revealed that MTDH mRNA expression was still obviously increased in the union dataset. (C, D) Compared with matched paracancerous normal kidney tissues, MTDH mRNA expression was increased in 80.6%(58/72) and 98.0%(99/101) of ccRCC tissues in TCGA dataset and GSE40435, respectively.