Figure 4. SENP1 promotes UBE2T signaling pathway. (A, B) SENP1 knockout inhibited the mRNA level of UBE2T, which was reversed by UBE2T overexpression. (C, D) SENP1 knockout inhibited the activation of Akt, which was reversed by UBE2T overexpression. (E) UBE2T overexpression weakened the effect of SENP1 knockout in P53, P21 and CyclinD1 levels. The representative images were selected from at least three independent experiments. *P<0.05, **P<0.01, ***P<0.001.