Research Paper Volume 12, Issue 2 pp 1563—1576

SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T

Figure 7. SENP1 knockout attenuates the tumorigenic potential in vivo. (A) Tumor growth of mice injected with HepG2-control or HepG2-SENP1 KO. (B) Representative tumors of negative control groups and SENP1 KO groups. (C) The average final tumor size and weight in negative control groups and SENP1-KO groups. (D) UBE2T expression in xenograft tumor tissues by immunohistochemical staining. (E) UBE2T, p-Akt and Akt protein levels in xenograft tumor tissues by Western blot. (F) P53 and P21 mRNA levels in xenograft tumor tissues by RT-PCR. (G) The schematic diagram briefly demonstrating the molecular mechanism of SENP1 mediated promotion of HCC. The representative images were selected from at least three independent experiments. *P<0.05, **P<0.01, ***P<0.001.