Research Paper Volume 12, Issue 2 pp 1610—1623

Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the SIRT2-dependent H4K16 deacetylation pathway

Figure 7. Diagram illustrating the proposed mechanisms mediating the beneficial effects of melatonin on meiotic phenotypes of aged oocytes. Melatonin supplement induces SIRT2 expression in oocytes from old mice, which in turn decreases the acetylation levels of H4K16, and thereupon promoting the establishment of proper kinetochore-microtubule attachment and the assembly of meiotic apparatus.