Figure 4. ADRB3 stimulation promotes inflammatory cytokine and chemokine expression in old and obese female GWAT. Expression of liver inflammation genes - (A) Il6 (B) Mcp1 (C) Arg1 (D) Mgl1 (E) Cx3cr1 (F) Ccr2. Expression of GWAT inflammation genes - (G) Il6 (H) Mcp1 (I) Arg1 (J) Mgl1 (K) Cx3cr1 (L) Ccr2 in lean and obese male and female GWAT with and without ADRB3 stimulation. A.U., arbitrary units normalized to Gapdh, N=5-8. One-way ANOVA with Student’s t-test was performed for (A–L). Statistical significance is indicated by *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001; error bars are SEM.