Research Paper Volume 12, Issue 2 pp 1792—1807

The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 may involve elevated levels of α7 nicotinic acetylcholine receptors

Figure 2. Effects of RSV and suramin on the expression of synapse makers, p-CREB, GFAP as well as Iba-1, in mice carrying the APP/PS1 double mutation. (A) the level of SYP protein; (B) SNAP-25; (C) p-CREB; (D) GFAP and (E) Iba-1. The values presented are means ± SD. *P<0.05 compared with the WT group; #P<0.05 compared with the APP/PS1 group, as determined by analysis of variance (ANOVA), followed by the Tukey HSD test. Representative western blots are shown beneath D and F. Representative western blots are shown beneath each bar graph.