Research Paper Volume 12, Issue 2 pp 1792—1807

The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 may involve elevated levels of α7 nicotinic acetylcholine receptors

Figure 3. In vivo and in vitro imaging of in mice carrying the APP/PS1 double mutation at different time-points after intravenous (i.v.) injection of the Aβ probe (CRANAD-58). The wild-type (WT) animals received physiological saline (PS) and the APP/PS1 mice RSV (APP/PS1+R): 20 mg/kg or suramin (APP/PS1+S): 20 mg/kg by gavage once daily for two months. (A) Representative images of 10 min after injection of the probe. (a) Quantitation of the fluorescent signals in (A). (B) Representative images of 20 min after injection of the probe. (b) Quantitation analysis of the fluorescent signals in (B). Fluorescent signals were detected with excitation at 630 nm and emission at 750 nm. The values presented are means ± SD. *P<0.05 and **P<0.01 compared to the WT group; #P<0.05 and ##P<0.01 compared to the APP/PS1 group.