Figure 4. Effects of RSV and suramin on the level of Aβ in mouse brain, as determined by confocal laser scanning. The wild-type (WT) animals received physiological saline (PS) and APP/PS1 mice RSV (APP/PS1+R): 20 mg/kg or suramin (APP/PS1+S): 20 mg/kg by gavage once daily for two months. (A) Aβ deposits in the hippocampus (×100 and ×400). (a) The integral optical density (IOD) of Aβ in the hippocampus. (B) Aβ deposits in the temporal cortices (×100 and ×400). (b) The IOD of Aβ in the temporal cortices. The values presented are means ± SD. *P<0.05 and **P<0.01 compared to the WT group; #P<0.05 and ##P<0.01 compared to the APP/PS1 group, as determined by analysis of variance (ANOVA), followed by the Tukey HSD test.