Research Paper Volume 12, Issue 2 pp 1792—1807

The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 may involve elevated levels of α7 nicotinic acetylcholine receptors

Figure 4. Effects of RSV and suramin on the level of Aβ in mouse brain, as determined by confocal laser scanning. The wild-type (WT) animals received physiological saline (PS) and APP/PS1 mice RSV (APP/PS1+R): 20 mg/kg or suramin (APP/PS1+S): 20 mg/kg by gavage once daily for two months. (A) Aβ deposits in the hippocampus (×100 and ×400). (a) The integral optical density (IOD) of Aβ in the hippocampus. (B) Aβ deposits in the temporal cortices (×100 and ×400). (b) The IOD of Aβ in the temporal cortices. The values presented are means ± SD. *P<0.05 and **P<0.01 compared to the WT group; #P<0.05 and ##P<0.01 compared to the APP/PS1 group, as determined by analysis of variance (ANOVA), followed by the Tukey HSD test.