Figure 8. ISG20 positively regulated the expression of MMP9/CCND1 in ccRCC. (A–B) GSEA revealed that the high ISG20 expression group was associated with metastasis pathways and cell cycle pathways. (C) The expression of MMP9 and CCND1 were down-regulated in ccRCC cells with knockdown of ISG20. (D) The expression of MMP9 and CCND1 were elevated in the TCGA KIRC dataset and ccRCC tissues. (E) The schematic representation of elevated the expression of ISG20 could drive tumor progression via up-regulating the expression of MMP9/CCND1. ccRCC: clear cell renal cell carcinoma; TCGA KIRC: The Cancer Genome Atlas Kidney Clear Cell Carcinoma. Data are represented as mean ± SD. ***, P < 0.001; **, P < 0.01; *, P < 0.05.