Figure 1. Differentially expressed genes between two representative sets of samples, Venn diagram, PPI network and the most significant module of DEGs. Data from GSE45050 (A), GSE84598 (B), and GSE89377 (C). Red: Upregulated genes (FC > 1.0 and a corrected P-value < 0.05); Blue: Downregulated genes (FC < 1.0 and a corrected P-value < 0.05). Black: genes with no significant differential expression. (D) 155 DEGs (absolute FC > 1 and P-value < 0.05) shared among the three mRNA expression profiling datasets GSE45050, GSE84598 and GSE89377. (E) PPI network of DEGs constructed in Cytoscape. (F) The most significant module obtained from PPI network, with 11 nodes and 58 edges. Upregulated genes are marked in light red; downregulated genes are marked in light blue. Abbreviations: FC, fold change; GEO, Gene Expression Omnibus; DEGs, differentially expressed genes; PPI, protein–protein interaction.