Figure 2. Protein-protein interaction network and analysis of the hub genes. (A) The 10 most important hub genes identified using the Cytoscape software plugin cytoHubba. (B) Genes co-expressed with hub genes identified by cBioPortal. Nodes with bold black outline represent hub genes. Nodes with thin black outline represent the co-expressed genes. (C) Hierarchical clustering heatmap of 10 most important hub genes was constructed depend on TCGA cohort. Red indicates that the expression of genes is relatively upregulated, green indicates that the expression of genes is relatively downregulated, and black indicates no significant changes in gene expression; gray indicates that the signal strength of genes was not high enough to be detected. Abbreviation: TCGA, The Cancer Genome Atlas.