Figure 5. (A–H) significantly correlated genes and hallmarks gene sets enriched in HCC DEGs obtained by GSEA. A total of 100 significant genes were obtained by GSEA with positive and negative correlation. The most significant pathways included cell cycle, DNA replication, endocytosis, P53 signaling pathway, progesterone mediated oocyte maturation, RNA degradation, spliceosome, and ubiquitin mediated proteolysis. (I) Transcriptional expression profiles of the 100 most significant genes are shown as the heat map.