Research Paper Volume 12, Issue 2 pp 2005—2017

Late-life obesity is a protective factor for prodromal Alzheimer’s disease: a longitudinal study

Figure 1. The cross-sectional associations of BMI categories with CSF biomarker levels in the whole population and the subgroups stratified by cognitive diagnosis. (A) Higher late-life BMI categories were associated with a higher level of CSF Aβ42 and lower levels of CSF t-tau (B) and CSF t-tau/Aβ42 (C). All analyses were adjusted for age, sex, education, cognitive diagnosis, ApoE ε4 status, CSF volume and prevalent comorbidities (i.e., hypertension, hyperlipemia, DM2, depression and CVD). Abbreviations: BMI = body mass index; MCI = mild cognitive impairment; NC = normal cognition; Aβ42 =β-amyloid42; t-tau = total-tau.