Research Paper Volume 12, Issue 2 pp 2005—2017

Late-life obesity is a protective factor for prodromal Alzheimer’s disease: a longitudinal study

Figure 3. The longitudinal associations of BMI categories with cognitive performance in the entire sample. Higher BMI categories were associated with slower rates of cognitive decline on ADAS-Cog11 (A), ADAS-Cog13 (B), MMSE (C), ADNI-EF (D) and ADNI-MEM (E) over the following ten years. All analyses were adjusted for age, sex, education, cognitive diagnosis, ApoE ε4 status, as well as prevalent comorbidities (i.e., hypertension, hyperlipemia, DM2, depression and CVD). Abbreviations: BMI = body mass index; ADAS-Cog = Alzheimer Disease Assessment Scale-cognitive subscale; MMSE = Mini-Mental State Examination.