Research Paper Volume 12, Issue 7 pp 5651—5674

Intermedin1-53 attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1

Figure 7. A working model of mechanism through which IMD attenuates aging-associated vascular calcification. IMD upregulates sirt1 expression and deacetylase activity via combining CRLR/RAMPs receptor complex and activating PI3K/Akt, AMPK and cAMP/PKA signaling. Upregulation of sirt1 by IMD inhibits VSMC osteogenic transdifferentiation and VSMC senescence, thus preventing the development of aging-associated vascular calcification. LY=LY294002, CC=Compound C.