Research Paper Volume 12, Issue 8 pp 6570—6585

Long non-coding RNA MALAT1 exacerbates acute respiratory distress syndrome by upregulating ICAM-1 expression via microRNA-150-5p downregulation

Figure 5. Downregulated MALAT1 or upregulated miR-150-5p alleviates lung injury. (A) HE staining (× 400) of lung tissues from healthy control and ARDS mice. * p < 0.05 vs. healthy control mice. (B) Lung tissue injury score of healthy control and ARDS mice. * p < 0.05 vs. healthy control mice. (C) PaO2 of healthy control and ARDS mice. * p < 0.05 vs. healthy control mice. (D) The number of total cells, neutrophils, and macrophages in BAL of healthy control and ARDS mice. * p < 0.05 vs. healthy control mice. (E) The concentration of total protein, albumin, and IgM in BAL of healthy control and ARDS mice. (F) HE staining analysis of lung tissues of ARDS mice after injection with different lentiviruses (× 400). (G) Lung tissue injury score of ARDS mice after injection with different lentiviruses. (H) PaO2 in arterial blood of ARDS mice after injection with different lentiviruses. (I) The number of total cells, neutrophils and macrophages in BAL of ARDS mice. (J) The concentration of total protein, albumin, and IgM in BAL of ARDS mice after injection with different lentiviruses. * p < 0.05 vs. cells transfected with sh-MALAT1 NC or agomiR-150-5p NC. The data were measurement data and expressed as mean ± standard deviation. The data between two groups were analyzed by unpaired t-test. n = 8 for mice following each treatment.