Research Paper Volume 12, Issue 8 pp 6570—6585

Long non-coding RNA MALAT1 exacerbates acute respiratory distress syndrome by upregulating ICAM-1 expression via microRNA-150-5p downregulation

Figure 6. Schematic diagram illustrating MALAT1 upregulates ICAM-1 expression by binding to miR-150-5p and consequently stimulates HPMEC apoptosis and neutrophil adhesion, ultimately accelerating pulmonary inflammation and reducing lung permeability in ARDS mice.