Figure 11. Nrf2 deficiency exacerbated skeletal muscle loss during aging. (A, C) Representative images of the cross-sectional area (CSA) of extensor digitorum longus (EDL) and soleus (SOL) muscles by HE staining. (B, D) CSA of the EDL and SOL muscles in the young and old mice of WT and KO genotypes. Data represent mean ± SE, n=3. #P <0.05 main effect of age by two-way ANOVA. &P <0.05 main effect of genotype by two-way ANOVA.*P <0.05 Nrf2 KO vs WT mice of the same age.