Research Paper Volume 12, Issue 7 pp 5992—6017

PCNA-associated factor KIAA0101 transcriptionally induced by ELK1 controls cell proliferation and apoptosis in nasopharyngeal carcinoma: an integrated bioinformatics and experimental study

Figure 4. Down-regulation of KIAA0101 inhibits the proliferation and promotes apoptosis of NPC cells. (A) Reprehensive fluorescent graphs of shCtrl and shKIAA0101-1 NPC groups taken by Nexcelom Celigo Image Cytometer in five continuous days. (B) Statistical result of cell count/fold and growth curve. Data are presented as the mean ± SD from three independent experiments. **p<0.01, ***p<0.001, ****p<0.00001. (C) Downregulation of KIAA0101 suppressed colony formation ability of NPC cell line CNE-2Z (Left: bright field; Right: fluorescent field). (D) Apoptosis ratios of shKIAA0101 groups were increased compared with those in shCtrl group by flowcytometry. Histogram is the average cell apoptosis rate (mean ± SD) of three independent experiments. ****p<0.00001.