Research Paper Volume 12, Issue 7 pp 6018—6029

Reversal of multidrug resistance in leukemia cells using a transferrin-modified nanomicelle encapsulating both doxorubicin and psoralen

Figure 4. Targeted delivery system inhibition of P-gp expression levels. (A) The expression levels of P-gp in K562 cells and K562/DOX cells analyzed by fluorescence microscopy and (B) immunoblotting. The effects of various drug delivery system formulations on the delivery system were examined by (C) fluorescence microscopy (D) RT-PCR and (E) immunoblotting. Data are shown as mean ± standard deviations (n=3).